Regulatory
Operations

The engine behind on-time submissions

Why Operations Matters

Strategy Gets the Credit. Operations Gets It Filed.

Every regulatory milestone your company announces depends on an unglamorous machine working perfectly: documents versioned correctly, dossiers compiled and validated, gateways dispatching on schedule, correspondence tracked, archives ready for inspection. When that machine is healthy, nobody notices it. When it isn't, submission dates slip in public. We build and run regulatory operations for life sciences companies that intend to never explain a missed date to their board.

The Submission Lifecycle

Built Around the Life of a Submission.

Operations is not a list of services. It is one pipeline, and every handoff in it is a place where a filing can be delayed. We cover the entire path.

Plan

The calendar is the contract. Sequence strategy and content plans are set before the first document is authored.

  • Global submission calendars
  • Sequence and lifecycle planning
  • Content plans and placeholders
Author & Manage

Controlled documents, clean templates, and version discipline, so publishing never starts with cleanup.

  • Document management and templates
  • Version control and review workflows
  • Submission-ready formatting
Publish

Dossiers compiled, hyperlinked, and technically validated to pass the gateway on the first attempt.

  • eCTD compilation and hyperlinking
  • Technical validation and QC
  • Regional format requirements
Submit & Track

Gateway dispatch with acknowledgments confirmed, and every agency touchpoint logged where the whole team can see it.

  • ESG and EU gateway dispatch
  • Acknowledgment and validation tracking
  • Health authority correspondence logs
Archive & Maintain

A submission archive an inspector could open tomorrow, and lifecycle sequences that never lose the thread.

  • Audit-ready submission archives
  • Lifecycle sequence management
  • Legacy data and system migrations

A major filing on the calendar and no publishing capacity to meet it?

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Engagement Models

Run by Us, or Built With You.

Some teams need an operations function that simply works, starting now. Others need their own function designed, systematised, and handed over. We do both.

Run It For You

A managed regulatory operations desk. Your submissions are planned, published, dispatched, and tracked by senior operators who own the calendar with you.

  • Outsourced eCTD publishing, single sequences to full MAAs and NDAs
  • Submission calendar ownership and status reporting
  • Surge capacity for major filings and remediations
  • Ongoing lifecycle and variation publishing
  • Correspondence and commitment tracking
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Build It With You

An operations transformation engagement. We design the function, implement the systems, write the process, and train the team that will run it after we leave.

  • RIM and publishing platform selection and implementation
  • Process design, SOPs, and working instructions
  • Legacy submission and data migration
  • Submission metrics, dashboards, and governance
  • Team training and structured handover
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Platform Fluency

Fluent in the Systems You Already Own.

We work inside your environment rather than forcing ours on you. Our operators plan, publish, and dispatch in the platforms life sciences companies actually run.

eCTD & eCTD 4.0 Veeva Vault RIM LORENZ docuBridge EXTEDO eCTDmanager FDA ESG EMA Gateway & CESP EUDAMED SharePoint & Documentum
Operating Standards

What Disciplined Operations Looks Like.

We don't publish vanity metrics. We run to standards, and we put them in writing at the start of every engagement.

First-pass validation.

Submissions are engineered to clear technical validation the first time. Rework after a gateway rejection is treated as a process failure to be corrected, not a normal cost of doing business.

Dates are commitments.

A submission date that moves is an escalation, raised early with a recovery plan attached. It is never a surprise discovered in a status meeting.

Audit-ready by default.

The archive is maintained as if an inspector arrives tomorrow: complete sequences, reconciled correspondence, and documentation that matches what was actually sent.

Written down, not tribal.

Every process we run is documented well enough for someone else to run it. Your operation should survive any single person leaving, including us.

Who You're Working With

People Who Have Sat in the Publishing Seat.

Our regulatory operations leads have planned, published, and dispatched submissions to FDA, EMA, and national authorities under real deadline pressure. You aren't being staffed with junior consultants under a partner's name; you get the senior practitioner on every call.

Hands-On Operators

Leads who have personally compiled sequences, cleared validation errors at midnight, and pressed the dispatch button, not just managed people who did.

Senior-Only Engagement Model

The lead consultant on your engagement is the one doing the work. We don't bait-and-switch with junior staff after the contract is signed.

Systems and Process Fluency

Deep working knowledge of the RIM, publishing, and gateway landscape, applied to your environment rather than a preferred vendor's.

Global Gateway Experience

Submissions dispatched and tracked across US, EU, UK, and national procedures, with the regional format quirks handled before they cost you a validation cycle.

Work With Us

Ready to Make Submissions the Predictable Part?

Tell us what's on your submission calendar and what's standing in the way. We'll match you with a senior operations lead and respond within one business day. All inquiries are strictly confidential.

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